| Tyson Foods (poultry products) | 1,925 employees | |
| Jefferson Regional Medical Center (medical center) | 1,850 employees | |
| U.S. Army - Pine Bluff Arsenal (army depot) | 1,700 employees | |
| Ark. Dept. of Correction (correctional facility and administrative) | 1,490 employees | |
| Evergreen Packaging, Inc. (paperboard mill) | 1,100 employees | |
| Pine Bluff School District (public education) | 900 employees | |
| URS/Washington Group Division (chemical weapons disposal) | 735 employees | |
| University of Arkansas at Pine Bluff (state university) | 645 employees | |
| Union Pacific Railroad (main line railroad) | 630 employees | |
| Central Moloney, Inc. (electric transformers) |
540 employees | |
| NCTR (Federal research laboratory) | 525 employees |
